Mechanism of Action
Coumarin contained in Meliloto increases the proteolytic activity of macrophages, decreasing the number of macro proteins involved in the pathogenic mechanism of lymphoedema.
The Diosmin is a flavonoid of natural origin, classified among vasoprotective drugs. Its mechanism of action is based primarily on:
- Reinforcement and protection of the microcirculation via inhibitory activity of hyaluronidase, capillary vasoconstriction in potentiating action of adrenaline and ascorbic acid, and decreased vascular permeability.
- Antiedema action, mainly due to the decrease in vascular permeability.
- Inhibition of pain symptoms through anti-inflammatory action due to inhibition of lipoxygenase synthesis.